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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Updated: May 15, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Current and emerging technology approaches in genomics.

Yvette P Conley1, Leslie G Biesecker, Stephen Gonsalves

  • 1University of Pittsburgh, Pittsburgh, PA 15261, USA. yconley@pitt.edu

Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing
|January 9, 2013
PubMed
Summary
This summary is machine-generated.

Genomic approaches like genome sequencing and epigenomics are advancing our understanding of diseases. These methods are increasingly valuable for clinical assessment and personalized medicine.

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Area of Science:

  • Genomics and molecular biology.
  • Bioinformatics and computational biology.

Background:

  • Genomics is revolutionizing our understanding of health and disease.
  • Emerging genomic technologies offer new insights into complex conditions.

Purpose of the Study:

  • To introduce current and emerging genomic approaches.
  • To enable conceptual evaluation of genomic literature.
  • To highlight advancements in understanding health-related issues.

Main Methods:

  • Description of key genomic approaches: genome sequencing, genome-wide association studies, epigenomics, and gene expression.
  • Discussion of research advancement, clinical utility, current uses, and technological challenges.
  • Inclusion of web-based resources for further learning.

Main Results:

  • Genome sequencing, GWAS, epigenomics, and gene expression are vital for research data collection.
  • These approaches enhance understanding of disease pathophysiology.
  • Genomic methods are increasingly utilized for clinical assessment and testing.

Conclusions:

  • Genomic insights are crucial for developing advanced screening and diagnostic tests.
  • Understanding molecular underpinnings aids in prognostication and individualized treatments.
  • Genomics supports improved post-treatment surveillance strategies.