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Aspirin and aspirin resistance in coronary artery disease

Charalampos Kasmeridis1, Stavros Apostolakis, Gregory Y H Lip

  • 1University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK.

Current Opinion in Pharmacology
|January 9, 2013
PubMed

Insights

Aspirin resistance, where patients don't fully benefit from aspirin therapy, is a complex issue. This review examines its impact on preventing coronary artery disease.

Area of Science:

  • Cardiology
  • Pharmacology
  • Thrombosis

Background:

  • Aspirin is a primary antiplatelet therapy for secondary prevention of coronary artery disease.
  • Some patients exhibit aspirin resistance, not achieving expected antithrombotic effects.
  • The clinical and laboratory aspects of aspirin resistance are debated, with challenges to its existence.

Purpose of the Study:

  • To review current data on the impact of aspirin resistance.
  • To explore its role in primary and secondary prevention of coronary artery disease.

Main Methods:

  • Literature review of recent data on aspirin resistance.
  • Analysis of clinical and laboratory perspectives on aspirin resistance.

Main Results:

  • Laboratory methods for diagnosing aspirin resistance lack standardization and show variability.
  • Mechanisms underlying aspirin resistance are not fully elucidated.
  • Poor patient compliance is often associated with aspirin resistance.

Conclusions:

  • The existence and clinical significance of aspirin resistance remain subjects of ongoing research and debate.
  • Further investigation is needed to understand aspirin resistance and its implications for cardiovascular disease prevention.

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