Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Long-Term Memory01:18

Long-Term Memory

Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct cell-type contributions and network topography of theta-nested gamma oscillations in the medial entorhinal cortex.

bioRxiv : the preprint server for biology·2026
Same author

Allogeneic blood transfusion after hip fracture: risk factors and associated outcomes.

Bulletin of the Hospital for Joint Disease (2013)·2026
Same author

Fast Spiking Interneurons Autonomously Generate Fast Gamma Oscillations in the Medial Entorhinal Cortex with Excitation Strength Tuning ING-PING Transitions.

eNeuro·2026
Same author

Effect of Delayed Cord Clamping on Respiratory Infection-Related Encounters in the First 6 Months of Life in an Urban Community Hospital.

International journal of pediatrics·2026
Same author

TREK1 Channels Shape Spindle-Like Oscillations, Neuronal Activity, and Short-Term Synaptic Plasticity in Thalamocortical Circuits.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Fast spiking interneurons autonomously generate fast gamma oscillations in the medial entorhinal cortex with excitation strength tuning ING-PING transitions.

bioRxiv : the preprint server for biology·2025
Same journal

Understanding vulnerability through variability: a longitudinal twin study linking sex differences in neurodiversity, neurodevelopment and X-linked genetic mechanisms.

Behavioural brain research·2026
Same journal

Hippocampal plasticity predicts behavioral lateralization and stress resilience in laying hen chicks.

Behavioural brain research·2026
Same journal

Effects of Retatrutide on Learning and Memory in Streptozotocin-Induced Male Diabetic Rats.

Behavioural brain research·2026
Same journal

Bacopa-Enriched Formulation Enhances Memory and Synaptic Plasticity in a Rat Model of Vascular Dementia.

Behavioural brain research·2026
Same journal

Prior exposure to methylphenidate attenuates ethanol-induced conditioned place preference in zebrafish.

Behavioural brain research·2026
Same journal

Plasma nectin-4 levels are associated with changes in executive function in patients with methamphetamine use disorder undergoing treatment.

Behavioural brain research·2026
See all related articles

Related Experiment Video

Updated: May 15, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

Place cell activation predicts subsequent memory.

R Jonathan Robitsek1, John A White, Howard Eichenbaum

  • 1Center for Memory and Brain, Boston University, Boston, MA 02215, United States.

Behavioural Brain Research
|January 9, 2013
PubMed
Summary
This summary is machine-generated.

Hippocampal place cells in rats predict memory accuracy. Neuronal activity differed significantly between correct and error trials, highlighting their role in episodic memory.

Keywords:
HippocampusPlace cellsSubsequent memory effect

More Related Videos

Classification of Neural Stem Cell Activation State In Vitro Using Autofluorescence
06:56

Classification of Neural Stem Cell Activation State In Vitro Using Autofluorescence

Published on: April 12, 2024

Heat-Induced Antigen Retrieval: An Effective Method to Detect and Identify Progenitor Cell Types during Adult Hippocampal Neurogenesis
09:38

Heat-Induced Antigen Retrieval: An Effective Method to Detect and Identify Progenitor Cell Types during Adult Hippocampal Neurogenesis

Published on: August 30, 2013

Related Experiment Videos

Last Updated: May 15, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

Classification of Neural Stem Cell Activation State In Vitro Using Autofluorescence
06:56

Classification of Neural Stem Cell Activation State In Vitro Using Autofluorescence

Published on: April 12, 2024

Heat-Induced Antigen Retrieval: An Effective Method to Detect and Identify Progenitor Cell Types during Adult Hippocampal Neurogenesis
09:38

Heat-Induced Antigen Retrieval: An Effective Method to Detect and Identify Progenitor Cell Types during Adult Hippocampal Neurogenesis

Published on: August 30, 2013

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Memory Research

Background:

  • The hippocampus is crucial for episodic memory.
  • Hippocampal place cells are thought to form spatial maps.
  • Their precise role in episodic memory remains unclear.

Purpose of the Study:

  • To investigate the contribution of hippocampal place cells to episodic memory.
  • To determine if place cell activity predicts memory performance.

Main Methods:

  • Recorded hippocampal neuronal activity in rats performing a T-maze alternation task.
  • Analyzed place cell firing patterns during memory-guided choices after a delay.

Main Results:

  • Differential place cell firing predicted correct choices, even in identical locations.
  • Most place cells showed distinct activity patterns on correct versus error trials.
  • Cells active during successful memory retrieval were less active during errors.

Conclusions:

  • Hippocampal place cells are directly involved in episodic memory formation and retrieval.
  • Place cell activation patterns can predict memory accuracy.
  • This links spatial coding mechanisms to the capacity for remembering unique experiences.