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Updated: May 15, 2026

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
Published on: March 12, 2015
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis
Elizabeth de Souza Neves1, André Luis Land Curi, Maira Cavalcanti de Albuquerque
1Laboratório de Pesquisa Clínica em Doenças Febris Agudas, Instituto de Pesquisa Clinica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ. elizabeth.neves@ipec.fiocruz.br
Introduction:
A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis.
Methods:
A case-control study was conducted among 30 patients and 90 controls.
Results:
Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease.
Conclusions:
Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.
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