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ZNF804A genotype modulates neural activity during working memory for faces.

David E J Linden¹, Thomas M Lancaster, Claudia Wolf

¹MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. LindenD@cardiff.ac.uk

Neuropsychobiology

|January 9, 2013

Summary

Genetic variants in ZNF804A influence working memory (WM) for faces, impacting right dorsolateral prefrontal cortex (rDLPFC) activity. This suggests a link between genetic susceptibility to schizophrenia and altered cognitive processing.

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Area of Science:

Neuroscience
Genetics
Cognitive Psychology

Background:

Genetic susceptibility to schizophrenia (SZ) is linked to altered brain function in working memory (WM) and face processing.
The ZNF804A gene variant rs1344706 is associated with psychosis risk and altered brain connectivity during WM.
Previous research has not examined the specific effects of ZNF804A on WM involving face processing.

Purpose of the Study:

To investigate the impact of the ZNF804A rs1344706 variant on brain activity during a face working memory task in healthy individuals.
To determine if genetic variations at rs1344706 are associated with similar neural alterations observed in schizophrenia patients performing a face WM task.

Main Methods:

Genotyping of healthy controls for the rs1344706 variant.
Utilizing functional magnetic resonance imaging (fMRI) during a face working memory task.
Comparing brain activation patterns between genotype groups.

Main Results:

The rs1344706 risk allele was associated with altered activation in the right dorsolateral prefrontal cortex (rDLPFC).
rDLPFC activation was task-dependent, indicating genotype-related differences in cognitive processing.
The identified rDLPFC alterations showed volumetric overlap with regions previously found to be affected in schizophrenia patients.

Conclusions:

Findings support a link between the rs1344706 variant and altered DLPFC activity during face working memory.
Working memory for faces may serve as a valuable intermediate phenotype for studying genetic susceptibility to psychosis.