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Cardiovascular endocrinology in 2012: PCSK9-an exciting target for reducing LDL-cholesterol levels

D John Betteridge1

  • 1Department of Diabetes and Endocrinology, University College Hospital, London, UK. j.betteridge@ucl.ac.uk

Nature Reviews. Endocrinology
|January 9, 2013
PubMed

Insights

Systemic administration of anti-PCSK9 antibodies significantly lowers LDL-cholesterol. This cholesterol-lowering effect is additive to statin therapy, helping more patients reach their goals.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Elevated LDL-cholesterol is a major risk factor for cardiovascular disease.
  • Statins are a cornerstone of lipid-lowering therapy.
  • PCSK9 (proprotein convertase subtilisin/kexin type 9) plays a key role in regulating LDL-receptor levels.

Purpose of the Study:

  • To evaluate the impact of anti-PCSK9 antibodies on LDL-cholesterol levels.
  • To assess the additive effects of anti-PCSK9 antibodies in combination with statin therapy.

Main Methods:

  • Systemic administration of anti-PCSK9 antibodies.
  • Monitoring of LDL-cholesterol levels.
  • Assessment of LDL-receptor activity.

Main Results:

  • Anti-PCSK9 antibodies induced significant reductions in LDL-cholesterol.
  • The LDL-receptor activity modulation by anti-PCSK9 antibodies was additive to statin therapy.

Conclusions:

  • PCSK9 inhibition is a potent therapeutic strategy for lowering LDL-cholesterol.
  • Combination therapy with anti-PCSK9 antibodies and statins may help more patients achieve lipid goals.

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