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Cardiovascular disease in CKD in 2012: moving forward, slowly but surely

Pranav S Garimella1, Mark J Sarnak

  • 1Division of Nephrology, Tufts Medical Center, Box 391, 800 Washington Street, Boston, MA 02111, USA.

Nature Reviews. Nephrology
|January 9, 2013
PubMed

Insights

Chronic kidney disease (CKD) significantly increases cardiovascular disease risk, prompting further research into its equivalence as a risk factor. Studies in 2012 advanced understanding but highlighted remaining questions in managing cardiovascular health for CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Chronic kidney disease (CKD) is strongly associated with elevated cardiovascular disease (CVD) risk.
  • The 2012 observational study reinforced the debate on whether CKD is a CVD risk equivalent.
  • Existing research has explored strategies to reduce cardiovascular risk in CKD patients.

Purpose of the Study:

  • To re-evaluate the classification of chronic kidney disease (CKD) as a cardiovascular disease (CVD) risk equivalent.
  • To review and synthesize findings from studies investigating cardiovascular risk mitigation in CKD.
  • To identify knowledge gaps and future research directions in managing CVD in CKD.

Main Methods:

  • Observational study analysis.
  • Literature review of studies on cardiovascular risk in CKD.
  • Synthesis of current evidence and identification of research trends.

Main Results:

  • Confirmation of high cardiovascular disease risk in patients with chronic kidney disease.
  • Evaluation of various methods aimed at mitigating cardiovascular risk within the CKD population.
  • Advancement in the understanding of CKD's impact on cardiovascular health.

Conclusions:

  • Chronic kidney disease (CKD) remains a significant independent risk factor for cardiovascular disease (CVD).
  • Further research is needed to clarify the precise relationship between CKD and CVD, and to optimize risk management strategies.
  • The 2012 findings necessitate ongoing investigation into CKD as a potential cardiovascular risk equivalent.

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