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Related Experiment Video

Updated: May 15, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

Group B streptococcus late-onset disease: 2003-2010.

Alberto Berardi1, Cecilia Rossi, Licia Lugli

  • 1Unità Operativa di Terapia Intensiva Neonatale, Azienda Ospedaliero-Universitaria Policlinico, Via del Pozzo, 71-41124 Modena (MO), Italy. berardi.alberto@policlinico.mo.it

Pediatrics
|January 9, 2013
PubMed
Summary

Group B Streptococcus (GBS) late-onset disease (LOD) is most common in preterm infants. Intrapartum antibiotics may lead to milder GBS infections and delayed symptom onset.

Related Experiment Videos

Last Updated: May 15, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

Area of Science:

  • Neonatal infections
  • Bacterial pathogenesis
  • Public health epidemiology

Background:

  • Limited population data exists for group B Streptococcus (GBS) late-onset disease (LOD).
  • Risk factors and transmission routes for GBS are not well understood.

Purpose of the Study:

  • To determine the incidence of GBS LOD.
  • To evaluate GBS infections and identify risk factors.

Main Methods:

  • A prospective cohort study was conducted over 8 years (2003-2010).
  • Maternal rectovaginal and breast milk cultures were collected from January 2007 upon LOD diagnosis.
  • Incidence data and maternal GBS status were analyzed.

Main Results:

  • The incidence rate of LOD was 0.32 per 1000 live births, with higher rates in preterm infants.
  • Sepsis and meningitis were the most common LOD classifications.
  • Maternal GBS carriage was common (64% rectovaginal), while GBS mastitis occurred in 6% of mothers.
  • Early LOD presentation correlated with adverse outcomes like brain lesions or death.
  • Intrapartum antibiotic exposure was linked to milder LOD presentations.

Conclusions:

  • Preterm neonates face the highest risk of LOD and mortality.
  • Maternal GBS carriage is prevalent at the time of LOD diagnosis.
  • Intrapartum antibiotics may influence LOD severity and presentation timing.