Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resources for screening the literature for glycan-related terms using PubAnnotation in GlyCosmos.

Glycobiology·2026
Same author

Establishing the Asia & Pacific Bioinformatics Joint Congress: a historic milestone in regional bioinformatics collaboration.

Briefings in bioinformatics·2025
Same author

Update and New Implementation of the MIRAGE Reporting Guidelines for Mass Spectrometry Experiments in Glycoscience.

Molecular & cellular proteomics : MCP·2025
Same author

Meeting report on the 1st GlyCosmos Symposium & Jamboree-community-driven expansion of glycan-binding molecules resources.

Glycobiology·2025
Same author

Meeting Report on the 1st Asia & Pacific Bioinformatics Joint Conference (APBJC 2024).

Genes to cells : devoted to molecular & cellular mechanisms·2025
Same author

Meeting report of the GlySpace Alliance and GaLSIC symposium.

Glycobiology·2025

Related Experiment Video

Updated: May 15, 2026

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

Introduction to informatics in glycoprotein analysis.

Kiyoko F Aoki-Kinoshita1

  • 1Department of Bioinformatics, Soka University, Aliso Viejo, CA, USA. kkiyoko@soka.ac.jp

Methods in Molecular Biology (Clifton, N.J.)
|January 9, 2013
PubMed
Summary
This summary is machine-generated.

Glycoprotein analysis tools are emerging, building on glycome informatics. Existing resources like Expasy, glycosciences.de, and databases such as GlycoProtDB aid in predicting glycosylation sites and understanding their context.

More Related Videos

Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography
11:01

Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography

Published on: January 18, 2020

A Quantitative Glycomics and Proteomics Combined Purification Strategy
11:38

A Quantitative Glycomics and Proteomics Combined Purification Strategy

Published on: March 8, 2016

Related Experiment Videos

Last Updated: May 15, 2026

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography
11:01

Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography

Published on: January 18, 2020

A Quantitative Glycomics and Proteomics Combined Purification Strategy
11:38

A Quantitative Glycomics and Proteomics Combined Purification Strategy

Published on: March 8, 2016

Area of Science:

  • Glycomics and Bioinformatics
  • Computational Biology
  • Structural Biology

Background:

  • Glycome informatics has advanced carbohydrate analysis, but glycoprotein and glycoconjugate analysis remains underdeveloped.
  • Tools for analyzing glycosylation sites predate the term 'glycome informatics'.

Purpose of the Study:

  • To review existing methods and tools for analyzing glycosylation sites on glycoproteins.
  • To highlight databases that support glycoprotein analysis and prediction.
  • To discuss future prospects for glycoprotein analysis tool development.

Main Methods:

  • Utilized existing computational tools for glycosylation site prediction (e.g., Expasy server).
  • Leveraged databases containing glycoprotein information (e.g., GlycoProtDB, UniProt, O-GlycBase).
  • Incorporated analysis of amino acid distribution around glycosylation sites in 3D space using Protein Data Bank (PDB) data.

Main Results:

  • Expasy server offers tools for N- and O-glycan glycosylation site prediction.
  • glycosciences.de provides analysis of amino acid distribution around glycosylation sites.
  • Databases like GlycoProtDB, UniProt, and O-GlycBase store valuable glycoprotein and glycosylation data.

Conclusions:

  • Current tools and databases provide foundational support for glycoprotein analysis.
  • Accumulation of consistent data in databases is crucial for advancing glycoprotein analysis tools.
  • Further development in this area holds significant promise for glycomic research.