Related Experiment Video

Updated: May 15, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Senescence regulation by mTOR

Vjekoslav Dulic1

  • 1Institut de Génétique Moléculaire, Montpellier, France. vjekoslav.dulic@igmm.cnrs.fr

Methods in Molecular Biology (Clifton, N.J.)
|January 9, 2013
PubMed

Insights

Cellular senescence, a key aging process, is linked to the mTOR pathway, a regulator of cell growth. This review explores their connection, highlighting the tumor suppressor p53

Area of Science:

  • Cellular biology
  • Molecular biology
  • Gerontology

Background:

  • Cellular senescence is an irreversible cell cycle arrest triggered by stress.
  • The mTOR pathway regulates cell metabolism and growth.
  • The tumor suppressor p53 is a common regulator of both senescence and mTOR signaling.

Purpose of the Study:

  • To review the evidence linking cellular senescence and the mTOR pathway.
  • To highlight the role of p53 in connecting these two processes.
  • To discuss the controversial role of mTOR in senescence and its implications for aging.

Main Methods:

  • Literature review of recent research on senescence, mTOR, and p53.
  • Analysis of studies investigating the interplay between these pathways.
  • Synthesis of current understanding and identification of research gaps.

Main Results:

  • Evidence suggests a link between cellular senescence and mTOR signaling.
  • The tumor suppressor p53 plays a critical role in integrating these pathways.
  • Recent findings offer new insights into the debated role of mTOR in senescence.

Conclusions:

  • The connection between senescence and mTOR, mediated by p53, is crucial for understanding aging.
  • Further research is needed to fully elucidate the complex role of mTOR in senescence.
  • This field holds significant relevance for aging research and age-related diseases.

More Related Videos

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Induction and Validation of Cellular Senescence in Primary Human Cells08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a rapamycin-insensitive companion...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...