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Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

Gene expression profile analysis of lymphomas.

Katia Basso1, Ulf Klein

  • 1Institute for Cancer Genetics, Columbia University, New York, NY, USA.

Methods in Molecular Biology (Clifton, N.J.)
|January 9, 2013
PubMed
Summary

Gene expression profiling analyzes the transcriptome to understand lymphoma pathogenesis. This approach aids in defining subtypes, identifying origins, and finding new diagnostic markers and therapeutic targets for lymphoid neoplasia.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genomics

Background:

  • Gene expression profiling offers powerful insights into lymphoid neoplasia.
  • Understanding lymphoma pathogenesis is crucial for developing effective treatments.

Purpose of the Study:

  • To present a comprehensive approach for analyzing lymphoma transcriptomes.
  • To leverage gene expression data for classifying lymphoma subtypes and identifying therapeutic strategies.

Main Methods:

  • Genome-wide transcriptome characterization.
  • Analysis of gene expression patterns in lymphomas and normal lymphocytes.

Main Results:

  • Enables definition of molecular lymphoma subtypes.
  • Facilitates identification of normal lymphocyte counterparts.

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  • Aids in discovering diagnostic markers and therapeutic targets.
  • Reveals affected signaling pathways in oncogenic transformation.

    • Conclusions:

    • Gene expression profiling is instrumental in advancing lymphoma research.
    • This methodology provides a framework for molecular subtyping and therapeutic target identification in lymphomas.