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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...

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Related Experiment Video

Updated: May 15, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

Genetics of heart failure.

Luís R Lopes1, Perry M Elliott

  • 1UCL Institute of Cardiovascular Science, London, UK.

Biochimica Et Biophysica Acta
|January 10, 2013
PubMed
Summary

Heart failure (HF) is a growing public health concern. Genetic predisposition and inherited myocardial diseases are key factors in HF development, driving research into its complex genetic architecture.

Area of Science:

  • Cardiology
  • Genetics
  • Public Health

Background:

  • Heart failure (HF) is a condition where the heart cannot meet the body's metabolic demands, posing a significant global health challenge.
  • Increasing HF prevalence highlights the need to understand its complex genetic underpinnings, including inherited forms of myocardial disease.
  • Genetic predisposition is implicated in common HF, with research increasingly linking specific genes to disease risk.

Purpose of the Study:

  • To review genetic insights into common heart failure (HF) from candidate gene and genome-wide association studies.
  • To describe the primary genetic causes of inherited heart muscle diseases.
  • To outline current challenges and future research directions in understanding HF genetics.

Main Methods:

  • Review of candidate gene studies.
Keywords:
Candidate gene studyCardiomyopathyGWASGeneticsHeart failureHigh-throughput sequencing

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An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

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Related Experiment Videos

Last Updated: May 15, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

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06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

  • Analysis of genome-wide association studies (GWAS).
  • Description of genetic cardiomyopathies.

    • Main Results:

    • Candidate gene and GWAS approaches have provided insights into the genetic architecture of common HF.
    • Mendelian inherited forms of myocardial disease represent a significant, though underestimated, cause of HF.
    • Genetic research is illuminating the pathways involved in both inherited and common forms of HF.

    Conclusions:

    • Understanding the genetic basis of HF is crucial for developing targeted diagnostics and therapies.
    • Further research is needed to unravel the complex genetic landscape of heart failure.
    • Integrating findings from inherited cardiomyopathies can inform strategies for managing common HF.