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A Mouse Model of Lumbar Spine Instability
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Spirocerca lupi-associated vertebral changes: a radiologic-pathologic study.

Robert M Kirberger1, Sarah J Clift, Erna van Wilpe

  • 1Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, South Africa. robert.kirberger@up.ac.za

Veterinary Parasitology
|January 10, 2013
PubMed
Summary
This summary is machine-generated.

Spirocerca lupi infection in dogs causes vertebral changes, but aberrant larval migration is not the primary cause of spondylitis. Mild, inconsistent inflammation suggests other factors may drive bone changes in canine spirocercosis.

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Area of Science:

  • Veterinary Pathology
  • Canine Infectious Diseases
  • Comparative Pathology

Background:

  • Spirocerca lupi infection in dogs can lead to esophageal masses, aortic changes, and caudal thoracic spondylitis.
  • Previous hypotheses suggested aberrant larval migration or inflammation secondary to aortic migration caused spondylitis.

Purpose of the Study:

  • To investigate the cause of spondylitis associated with Spirocerca lupi in dogs.
  • To evaluate the roles of aberrant larval migration and inflammation in the development of spondylitis.

Main Methods:

  • Histopathological examination (light and transmission electron microscopy) of vertebral lesions from ten necropsied dogs with radiographic evidence of spondylitis.
  • Analysis of transverse and sagittal sections from affected vertebrae, comparing them to spondylosis deformans and normal vertebrae.

Main Results:

  • Spondylitis changes involved periosteal new bone formation and hyperplastic periosteum, with some ventral longitudinal ligament involvement.
  • Distinguishing new bone in spondylitis from spondylosis deformans was challenging.
  • Inflammation was mild and inconsistent in spondylitis cases; Spirocerca eggs were rarely observed in histologic sections.

Conclusions:

  • Aberrant larval migration is unlikely to be the predominant cause of spondylitis in canine spirocercosis.
  • Mild and inconsistent inflammation suggests other factors, potentially inflammatory mediators or osteoproliferative growth factors linked to the esophageal lesion or the parasite, may be involved.
  • Further research is needed to elucidate the exact mechanisms driving osteoproliferation in Spirocerca-associated spondylitis.