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Descriptive epidemiology of rotavirus infection in a community in North India

T R Chandola1, S Taneja, N Goyal

  • 1Centre for Health Research and Development, Society for Applied Studies, New Delhi, India.

Epidemiology and Infection
|January 10, 2013
PubMed

Insights

Rotavirus gastroenteritis is common in Indian infants, with high incidence rates in the first year of life. Understanding rotavirus genotypes like G1P[8] and G9P[4] is crucial for vaccine development and public health planning.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Rotavirus infections are a leading cause of child mortality in India, with an estimated 98,621 deaths annually.
  • Urban areas in Delhi experience significant rotavirus burden, necessitating local epidemiological data.

Purpose of the Study:

  • To estimate the incidence of rotavirus gastroenteritis and identify common rotavirus genotypes in urban Delhi children.
  • To inform the planning of rotavirus vaccine efficacy trials.

Main Methods:

  • Two cohorts of infants were enrolled: cohort 1 (aged <1 week) and cohort 2 (aged 12 months).
  • Children were followed for one year to assess gastroenteritis episodes, with rotavirus testing performed.
  • Genotyping of rotavirus strains was conducted for positive samples.

Main Results:

  • Rotavirus was detected in 14% (30/210) of gastroenteritis episodes.
  • Incidence rates of rotavirus gastroenteritis were 0.18 episodes/child-year in the first year and 0.14 episodes/child-year in the second year.
  • Severe rotavirus gastroenteritis occurred at a rate of 0.05 episodes/child-year in the first year, with no cases in the second year. The predominant genotypes were G1P[8] (27%) and G9P[4] (23%).

Conclusions:

  • Severe rotavirus gastroenteritis is a significant concern during the first year of life in urban Delhi.
  • The identified common rotavirus genotypes provide valuable information for vaccine strain selection and efficacy assessments.
  • These findings highlight the importance of rotavirus surveillance and vaccination strategies in India.

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