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Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke.
Zhifeng Qi1, Wenlan Liu, Yumin Luo
1Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, No,45 Changchun Street, Beijing, 100053, China. kliu@salud.unm.edu.
Normobaric hyperoxia (NBO) improves oxygen delivery to the brain, offering neuroprotection for ischemic stroke. This accessible therapy can slow brain injury and "buy time" for reperfusion treatments.
Area of Science:
- Neurology
- Emergency Medicine
- Physiology
Background:
- Stroke is a primary cause of death and disability.
- Ischemic stroke involves disrupted blood supply, leading to brain hypoxia and injury.
- The brain's high sensitivity to oxygen deprivation makes neuroprotection critical.
Purpose of the Study:
- To review current literature on Normobaric hyperoxia (NBO) for acute ischemic stroke.
- To explore NBO's neuroprotective mechanisms and therapeutic potential.
- To highlight NBO as a rapid, accessible, and cost-effective treatment strategy.
Main Methods:
- Literature review of studies on Normobaric hyperoxia in ischemic stroke.
- Analysis of proposed mechanisms of NBO neuroprotection.
- Evaluation of NBO's role in conjunction with other therapies.
Main Results:
- NBO enhances oxygen delivery to hypoxic brain tissues.
- Mechanisms include improved cerebral blood flow and reduced oxidative stress.
- NBO can mitigate ischemic damage, preserving tissue and "buying time" for reperfusion.
Conclusions:
- Normobaric hyperoxia is a promising neuroprotective strategy for acute ischemic stroke.
- Its accessibility and potential cost-effectiveness make it a valuable therapeutic option.
- Combining NBO with other treatments may offer superior outcomes.
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