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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: May 15, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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C-kit-mutated melanomas: the Chinese experience.

Lu Si1, Jun Guo

  • 1Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing, China.

Current Opinion in Oncology
|January 10, 2013
PubMed
Summary

C-kit mutations are found in Chinese melanoma patients, making c-kit a target for therapy. Imatinib shows promise in treating metastatic melanoma with c-kit alterations, improving survival rates.

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Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Malignant melanoma is a leading cause of cancer mortality.
  • Mucosal and acral melanomas are prevalent in Chinese populations, unlike Caucasians.
  • Genetic mutations in the c-kit gene are implicated in these melanoma subtypes.

Purpose of the Study:

  • To review c-kit-targeted molecular therapy for melanoma.
  • To discuss experiences with Chinese melanoma patients.
  • To highlight c-kit as a molecular target for melanoma treatment.

Main Methods:

  • Review of recent proceedings in c-kit-targeted molecular therapy.
  • Analysis of experiences in Chinese melanoma patients.
  • Examination of c-kit gene mutations and imatinib efficacy.

Main Results:

  • Somatic c-kit gene mutations detected in 10.8% of Chinese melanoma patients.
  • Imatinib demonstrated efficacy in metastatic melanoma patients with c-kit mutations.
  • Progression-free and overall survival may be increased by imatinib in selected patients.

Conclusions:

  • C-kit is a viable molecular target for metastatic melanoma therapy.
  • Imatinib is effective and well-tolerated for metastatic melanoma.
  • Imatinib shows potential as a therapeutic agent for melanoma patients with c-kit alterations.