Meninigitis immunisation: challenges, successes and new developments

Jacqueline Boulton1

  • 1Florence Nightingale School of Nursing and Midwifery, King's College, London, UK.

British Journal of Nursing (Mark Allen Publishing)
|January 10, 2013
PubMed

Insights

Bacterial meningitis remains a serious threat despite available vaccines, causing thousands of cases annually in the UK. Advances in vaccine technology offer hope for new immunisations against Neisseria meningitidis B, a leading cause of the disease.

Area of Science:

  • Medical Microbiology
  • Immunology
  • Public Health

Background:

  • Meningitis, inflammation of the brain and spine lining, is caused by bacteria, viruses, and fungi.
  • Bacterial meningitis is a severe form, responsible for approximately 170,000 global deaths annually.
  • Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type B are the primary bacterial culprits.

Purpose of the Study:

  • To review the historical development of meningitis vaccination.
  • To examine challenges faced by nurses in implementing immunisation policies.
  • To discuss advancements in vaccine technology for Neisseria meningitidis B.

Main Methods:

  • Literature review of vaccination history and policy.
  • Analysis of current immunisation schedules.
  • Exploration of emerging vaccine technologies.

Main Results:

  • Despite existing vaccines, over 3400 cases of bacterial meningitis and septicaemia occur yearly in the UK and Ireland.
  • Neisseria meningitidis B is identified as the leading cause of meningitis in the UK.
  • Vaccine technology is advancing, with potential for new immunisations.

Conclusions:

  • Bacterial meningitis continues to pose a significant public health challenge.
  • Nurses play a crucial role at the intersection of immunisation policy and public perception.
  • Ongoing research and technological advancements are vital for developing improved meningitis vaccines.

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Vaccinations01:51

Vaccinations

Overview
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...