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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Related Experiment Video

Updated: May 15, 2026

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model
08:06

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

Stem cell application in acute burn care and reconstruction.

C J Lewis1

  • 1Bradford Plastic Surgery and Burns Research Unit, Bradford, UK. drchristopherlewis@gmail.com

Journal of Wound Care
|January 10, 2013
PubMed
Summary

Stem cell therapy shows promise for burn patients, offering new tissue engineering options. Further research is needed to safely use stem cells from bone marrow, fat, and hair follicles in clinical burn care.

Area of Science:

  • Regenerative Medicine
  • Burn Injury Research
  • Stem Cell Biology

Background:

  • Burn injuries cause high mortality and morbidity, primarily from sepsis and inflammation.
  • Limited autologous skin graft availability complicates wound closure in burn patients.
  • Alternative tissue engineering sources, like stem cells, are being explored.

Purpose of the Study:

  • To provide a commentary on the evidence for stem cell therapy in acute burn care.
  • To discuss the role of stem cells in tissue reconstruction for burn injuries.
  • To highlight stem cells from bone marrow, adipose tissue, and hair follicles.

Main Methods:

  • Review and commentary on existing scientific literature.
  • Analysis of evidence supporting stem cell applications in burn management.

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A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

Related Experiment Videos

Last Updated: May 15, 2026

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model
08:06

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
02:49

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

  • Focus on stem cells derived from bone marrow, fat, and hair follicles.

    • Main Results:

    • Stem cells demonstrate significant potential in augmenting the clinical care of burn patients.
    • Advancements in stem cell biology have expanded understanding over the last two decades.
    • Further insight is required for safe and effective clinical translation of stem cell therapies.

    Conclusions:

    • Stem cell therapy offers a promising avenue for improving outcomes in acute burn care.
    • Utilizing stem cells from various sources like bone marrow, fat, and hair follicles is key for tissue engineering.
    • Continued research is essential to fully harness the potential of stem cells in patient care for burn injuries.