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Updated: May 15, 2026

An Improved Method for the Preparation of Type I Collagen From Skin
Published on: January 21, 2014
A novel surgical approach to calcinosis cutis using a collagen-elastin matrix
L Piombino1, T Pallara, A M Soltani
1Plastic and Reconstructive Surgery Unit, Biomedical University Campus of Rome, Italy.
Abstract:
Calcinosis cutis is a cutaneous disorder characterised by abnormal deposition of calcium in the dermis. Treatment of this condition has variable success rates and includes medical, topical and surgical management. Here we describe a case of a woman with a painful calcinosis lesion on the buttocks, treated with excision and application of a bovine collagen-elastin dermal regeneration template, a thin, porous membrane consisting of a native bovine type I, II and V collagen-fibre template coated with elastin hydrolysate. The patient's wound healed without complication and without the use of a skin graft. She remains recurrence free at 10-month follow up, with satisfactory outcome.

