Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of premorbid nutritional status on TB severity.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
Same author

Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study.

medRxiv : the preprint server for health sciences·2024
Same author

Observation versus intervention for incidental common bile duct stones at intraoperative cholangiogram: a systematic review.

ANZ journal of surgery·2023
Same author

Spring and latch dynamics can act as control pathways in ultrafast systems.

Bioinspiration & biomimetics·2023
Same author

Implementing Genomic Testing for Lung Cancer Into Routine Clinical Practice - The Welsh Experience.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same author

Rectal 3D MRI modelling for benign and malignant disease.

The British journal of surgery·2020

Related Experiment Video

Updated: May 15, 2026

Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors
10:17

Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors

Published on: October 9, 2016

More effective cell-based therapy through biofilm suppression.

R D Wolcott1, S Cox

  • 1Southwest Regional Wound Care Centre, Texas, USA. randy@randallwolcott.com

Journal of Wound Care
|January 10, 2013
PubMed
Summary
This summary is machine-generated.

Targeted biofilm suppression combined with cell-based therapy (CBT) may enhance wound healing. This approach aims to improve wound bed preparation for better treatment outcomes in chronic wounds.

More Related Videos

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
06:50

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms

Published on: September 16, 2022

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
09:39

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

Related Experiment Videos

Last Updated: May 15, 2026

Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors
10:17

Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors

Published on: October 9, 2016

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
06:50

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms

Published on: September 16, 2022

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
09:39

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

Area of Science:

  • Wound healing research
  • Regenerative medicine
  • Microbiology of chronic wounds

Background:

  • Chronic wounds often harbor bacterial biofilms, hindering healing.
  • Cell-based therapy (CBT) shows promise for wound repair.
  • Biofilm presence can impede the efficacy of conventional and advanced therapies.

Purpose of the Study:

  • To evaluate if targeted biofilm suppression enhances cell-based therapy (CBT) for wound healing.
  • To assess the impact of biofilm-based wound management on CBT outcomes.
  • To compare outcomes of CBT with and without concurrent biofilm suppression.

Main Methods:

  • Retrospective study comparing patient cohorts.
  • Biofilm-based wound management involved simultaneous strategies to suppress wound biofilm.
  • Comparison with published data from randomized controlled trials on standard care and CBT.
  • Focus on targeting individual wound bioburden and improving wound-bed preparation.

Main Results:

  • The study aimed to determine the efficacy improvement of CBT when combined with biofilm suppression.
  • Analysis focused on comparing outcomes between the intervention group and historical controls.
  • Results are pending further analysis of comparative data.

Conclusions:

  • Targeted biofilm suppression alongside CBT may represent a synergistic approach to wound healing.
  • Optimizing the wound environment by managing biofilm is crucial for therapeutic success.
  • Further research is warranted to validate these findings in prospective trials.