Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.0K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.0K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

869
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
869

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corneal sub-basal nerve fiber plexus tortuosity in eyes with ectasia susceptibility and keratoconus: A cross-sectional in vivo confocal microscopy study.

The ocular surface·2026
Same author

Corneal Allograft for Near Vision Improvement in Emmetropic Presbyopia: 4-Year Safety and Efficacy Results From a Prospective European Multicenter Clinical Trial.

Journal of refractive surgery (Thorofare, N.J. : 1995)·2026
Same author

Impact of Donor Lenticule Depth on the Outcome of Allogeneic Corneal Inlay Treatment for Presbyopia.

Cornea·2026
Same author

[Sugammadex for anaphylaxis due to rocuronium].

Die Anaesthesiologie·2025
Same author

Fit-for-Future: Lessons Learned from the COVID-19 Pandemic in Primary Extracorporeal Membrane Oxygenation (ECMO) Transports of Acute Respiratory Distress Syndrome (ARDS) Patients.

Journal of clinical medicine·2024
Same author

Crosslinking with UV-A and riboflavin in progressive keratoconus: From laboratory to clinical practice - Developments over 25 years.

Progress in retinal and eye research·2024

Related Experiment Video

Updated: Dec 15, 2025

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

8.1K

The efficacy of corneal cross-linking shows a sudden decrease with very high intensity UV light and short treatment

Jeremy Wernli1, Silvia Schumacher, Eberhard Spoerl

  • 1IROC Science to Innovation AG, Zurich, Switzerland. jeremy.wernli@irocscience.com

Investigative Ophthalmology & Visual Science
|January 10, 2013
PubMed
Summary

Corneal cross-linking strengthens corneas up to 45 mW/cm² intensity and 2-minute duration. Higher intensities or shorter times, even with sufficient total dose, do not show significant biomechanical strengthening in porcine eyes.

More Related Videos

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.2K
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.3K

Related Experiment Videos

Last Updated: Dec 15, 2025

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

8.1K
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.2K
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.3K

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Progressive keratectasia necessitates effective treatments.
  • Standard treatment involves UV-triggered corneal cross-linking.
  • Insufficient evidence exists for biomechanical strengthening at high irradiances (>10 mW/cm²) and short treatment times (<10 minutes).

Purpose of the Study:

  • To investigate the biomechanical strengthening of ex vivo corneal tissue using varying UV irradiances and illumination times.
  • To determine the effective range of the Bunsen-Roscoe reciprocity law in corneal cross-linking.
  • To assess the impact of different UV-A intensities and durations on corneal stiffness.

Main Methods:

  • 100 porcine eyes underwent riboflavin + UV treatment with varying intensities (3-90 mW/cm²) and durations (1-30 minutes) at a constant irradiation dose (5.4 J/cm²).
  • A control group (80 eyes) received no UV irradiation.
  • Uniaxial stress-strain measurements determined Young's modulus at 10% strain; Kruskal-Wallis test was used for statistical analysis.

Main Results:

  • Significant biomechanical strengthening (p < 0.01) was observed in treatment groups up to 45 mW/cm² (2-30 minutes illumination).
  • No significant difference in Young's modulus was found between the control group and treatment groups using 50-90 mW/cm² ( <2 minutes illumination).
  • The Bunsen-Roscoe reciprocity law appeared valid up to 40-50 mW/cm² and durations exceeding 2 minutes.

Conclusions:

  • Corneal cross-linking efficacy is dependent on both UV irradiance and illumination time, with reciprocity holding up to approximately 40-50 mW/cm².
  • Higher irradiances (>50 mW/cm²) with shorter treatment times (<2 minutes) did not yield significant biomechanical strengthening in ex vivo porcine corneas.
  • Further in vivo studies on human corneal tissue are required, including safety assessments at high irradiances.