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Aspirin and clopidogrel for prevention of ischemic stroke

Ruth M Thomson1, David C Anderson

  • 1Department of Neurology, University of Minnesota, 420 Delaware St. SE, MMC 295, Minneapolis, MN 55455, USA. Thom1824@umn.edu

Current Neurology and Neuroscience Reports
|January 10, 2013
PubMed

Insights

Platelets play a key role in ischemic stroke. While current guidelines don't favor dual antiplatelet therapy, research suggests combined aspirin and clopidogrel may benefit secondary stroke prevention.

Area of Science:

  • Neuroscience
  • Hematology
  • Pharmacology

Background:

  • Platelets are crucial in ischemic stroke pathogenesis.
  • Understanding platelet activation is key to developing antithrombotic therapies.

Purpose of the Study:

  • To review the role of platelets in ischemic stroke.
  • To evaluate antiplatelet agents like aspirin and clopidogrel.
  • To explore the potential of combination therapy and antiplatelet resistance.

Main Methods:

  • Literature review of platelet function in ischemic stroke.
  • Analysis of antithrombotic agent efficacy and safety.
  • Examination of resistance mechanisms and diagnostic testing.

Main Results:

  • Current guidelines do not recommend combined aspirin and clopidogrel.
  • Emerging research suggests potential benefits of dual antiplatelet therapy in specific cases.
  • Optimal antiplatelet therapy involves considerations of efficacy, safety, and resistance.

Conclusions:

  • Dual antiplatelet therapy with aspirin and clopidogrel may have specific roles in secondary ischemic stroke prevention.
  • Cautious interpretation of literature is advised before clinical application.
  • Adherence to current guidelines for secondary stroke prevention remains the primary recommendation.

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