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Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview

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Mapping Dysfunctional Protein-Protein Interactions in Disease
09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

Chapter 4: Protein interactions and disease.

Mileidy W Gonzalez1, Maricel G Kann

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America.

Plos Computational Biology
|January 10, 2013
PubMed
Summary
This summary is machine-generated.

Protein interactions are crucial for biological functions and disease development. Mapping these networks computationally and experimentally aids in understanding disease mechanisms and developing new treatments.

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Last Updated: May 15, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
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Published on: October 24, 2025

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
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Imaging Protein-protein Interactions in vivo
11:15

Imaging Protein-protein Interactions in vivo

Published on: October 10, 2010

Area of Science:

  • Molecular Biology
  • Systems Biology
  • Bioinformatics

Background:

  • Proteins function through interactions with other molecules, mediating essential cellular processes.
  • These interactions are fundamental to both healthy physiological states and the development of diseases.
  • Mutations impacting protein binding sites or allosteric regulation can lead to disease.

Purpose of the Study:

  • To describe computational and experimental methods for predicting and detecting protein interactions.
  • To highlight the application of protein interaction networks in understanding human diseases.
  • To evaluate the challenges associated with using these networks in translational research.

Main Methods:

  • Computational approaches for predicting protein interaction networks.
  • Experimental techniques for detecting protein-protein interactions.
  • Network analysis to elucidate disease mechanisms.

Main Results:

  • Protein interaction networks provide insights into the molecular basis of diseases.
  • These networks can inform the development of diagnostic and therapeutic strategies.
  • The study reviews established and emerging methodologies in the field.

Conclusions:

  • Protein interaction networks are valuable tools for studying human diseases.
  • Understanding these networks facilitates the translation of basic research into clinical applications.
  • Addressing current challenges will enhance the utility of protein interaction network analysis.