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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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Related Experiment Video

Updated: May 15, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
14:29

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

Normal T cell selection occurs in CD205-deficient thymic microenvironments.

William E Jenkinson1, Kyoko Nakamura, Andrea J White

  • 1Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom. w.e.jenkinson@bham.ac.uk

Plos One
|January 10, 2013
PubMed
Summary
This summary is machine-generated.

The thymus screens T cells for proper function. This study investigated the role of CD205 in T cell development and found it does not significantly impact T cell selection or overall development within the thymus.

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Area of Science:

  • Immunology
  • Cell Biology
  • Developmental Biology

Background:

  • The thymus is crucial for T cell development, ensuring self-tolerance.
  • Cortical thymic epithelial cells (CTEC) present self-peptides to thymocytes for positive selection.
  • The source of self-peptides for selection is unknown, but apoptotic thymocytes are a potential source.

Purpose of the Study:

  • To investigate the role of the endocytic receptor CD205 in T cell development and selection.
  • To determine if CD205 mediates the uptake of apoptotic thymocytes for T cell repertoire shaping.

Main Methods:

  • Analysis of T cell development in CD205-deficient mice.
  • Examination of both polyclonal and monoclonal transgenic T cell receptor (TCR) T-cell development.
  • Assessing thymocyte development and selection processes.

Main Results:

  • CD205 deficiency did not overtly affect T cell development.
  • No significant impact on T cell selection was observed in the absence of CD205.
  • The study did not find evidence for a critical role of CD205 in shaping the T cell repertoire via apoptotic thymocyte uptake.

Conclusions:

  • CD205 does not appear to play a major role in normal thymocyte development or selection.
  • The uptake of apoptotic thymocytes by CTEC via CD205 is not essential for T cell repertoire formation.
  • Further research may be needed to explore other potential functions of CD205 in the immune system.