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Association between elevated pleural interleukin-33 levels and tuberculous pleurisy
Koung-Sun Lee1, Hak-Ryul Kim, Seongae Kwak
1Department of Laboratory Medicine, Wonkwang University School of Medicine, Iksan, Korea.
Annals of Laboratory Medicine
|January 10, 2013
Summary
Elevated pleural interleukin-33 (IL-33) levels are associated with tuberculous pleurisy. However, adenosine deaminase (ADA) and interferon-gamma (IFN-γ) remain superior diagnostic markers for this condition.
Area of Science:
- Pulmonary Medicine
- Immunology
- Infectious Diseases
Background:
- Interferon-gamma (IFN-γ) is critical in Mycobacterium tuberculosis-induced pleural responses.
- Interleukin-33 (IL-33) enhances IFN-γ production.
- The study investigates the link between pleural IL-33 and tuberculous pleurisy.
Purpose of the Study:
- To determine if pleural IL-33 levels are associated with tuberculous pleurisy.
- To evaluate the diagnostic value of pleural IL-33 in distinguishing tuberculous pleurisy from other pleural effusions.
Main Methods:
- Measured pleural and serum IL-33, ST2, adenosine deaminase (ADA), and IFN-γ in 220 patients.
- Included patients with tuberculous (TPEs), malignant (MPEs), parapneumonic (PPEs), and cardiogenic (CPEs) pleural effusions.
Main Results:
- Pleural and serum IL-33 levels were highest in TPE patients.
- Pleural IL-33 correlated with ADA and IFN-γ.
- Diagnostic accuracy of IL-33 was lower than ADA or IFN-γ for TPE.
Conclusions:
- An association exists between elevated pleural IL-33 and tuberculous pleurisy.
- Conventional markers ADA and IFN-γ are recommended for diagnosing TPE.
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