Related Experiment Video
Updated: May 15, 2026
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Imaging actinic keratosis by high-definition optical coherence tomography. Histomorphologic correlation: a pilot
Marc A L M Boone1, Sarah Norrenberg, Gregor B E Jemec
1Dermatology Department, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. dr.boone@scarlet.be
High-definition optical coherence tomography (HD-OCT) shows promise for non-invasively diagnosing and grading actinic keratosis. This high-resolution imaging technique visualizes cellular changes, correlating well with histopathology for improved clinical utility.
Area of Science:
- Dermatology
- Medical Imaging
- Optical Engineering
Background:
- Non-invasive therapies for actinic keratosis (AK) necessitate advanced diagnostic tools.
- High-definition optical coherence tomography (HD-OCT) offers micrometer resolution, bridging imaging gaps.
- Current diagnostic methods for AK require improvement in non-invasive monitoring.
Purpose of the Study:
- To assess the feasibility of HD-OCT for detecting and grading actinic keratosis.
- To compare HD-OCT findings with histopathological grading.
- To establish in vivo diagnostic criteria for AK using HD-OCT.
Main Methods:
- Pilot study involving 17 patients with histologically confirmed AK.
- Skin lesions imaged with HD-OCT prior to surgical excision.
- Qualitative analysis of HD-OCT images, comparing lesional and normal skin.
- Correlation of HD-OCT findings with histopathology.
Main Results:
- HD-OCT visualized dyskeratotic and atypical keratinocytes in lesional skin.
- Observed patterns included atypical honeycomb or disarranged epidermal layers.
- Good correlation found between spinous-granular layer atypia/disarrangement and histopathological grade.
- HD-OCT identified photodamage features in surrounding normal skin.
Conclusions:
- HD-OCT can detect and grade actinic keratosis in vivo.
- Established HD-OCT criteria align with histopathological findings.
- HD-OCT enhances clinical utility for actinic keratosis diagnosis and management.
More Related Videos
07:51Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
09:37Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022