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Related Experiment Video

Updated: May 15, 2026

Complete and Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Hemorrhagic Shock

Complete and Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Hemorrhagic Shock

Published on: May 19, 2022

Tranexamic acid in remote damage control resuscitation.

Joseph F Rappold¹, Anthony E Pusateri

¹Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA. joseph.rappold@tuhs.temple.edu

|January 11, 2013

Summary

This summary is machine-generated.

Tranexamic acid (TXA) is a valuable adjunct for controlling blood loss in massive transfusions. Studies show TXA significantly reduces mortality and bleeding deaths in trauma patients.

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Area of Science:

Trauma resuscitation
Hemorrhagic shock management
Pharmacologic hemostasis

Background:

Remote damage control resuscitation and far-forward surgery necessitate effective blood loss control.
Tranexamic acid (TXA) is a potential pharmacologic adjunct for patients requiring massive transfusions.

Purpose of the Study:

To review the current evidence on tranexamic acid (TXA) for managing blood loss in massive transfusion scenarios.
To examine the biologic and pharmacologic properties of TXA and its impact on mortality.

Main Methods:

Review of key clinical trials, including the CRASH-2 trial (2010) and the Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) study (2012).
Analysis of data on patient populations, mortality rates, and bleeding outcomes.

Main Results:

The CRASH-2 trial showed TXA reduced all-cause mortality from 16.0% to 14.5% and bleeding deaths from 5.7% to 4.9%.
The MATTERs study demonstrated a reduction in all-cause mortality from 23.9% to 17.4% in trauma patients receiving TXA.

Conclusions:

Tranexamic acid (TXA) demonstrates significant benefits in reducing mortality and bleeding in patients with massive transfusions.
Further research is needed to fully understand TXA's complications and optimize its use in trauma care.