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Related Experiment Video

Updated: May 15, 2026

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

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Published on: August 14, 2016

Propofol infusion syndrome or adrenoleukodystrophy?

Yucel Karaman¹, Aylin Goktay, Hasan Agin

¹Anesthesiology and Reanimation Clinic, Tepecik Research and Training Hospital, Izmir, Turkey. dr_ykaraman@hotmail.com

Paediatric Anaesthesia

|January 11, 2013

Summary

Propofol infusion syndrome (PRIS) can mimic other serious conditions. A child

Area of Science:

Neurology
Pediatrics
Metabolic Disorders

Background:

Propofol is a common anesthetic agent used in pediatric patients.
Propofol infusion syndrome (PRIS) is a rare but serious complication associated with prolonged propofol infusions.
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease affecting the central nervous system.

Observation:

A 5-year-old girl with spasticity experienced seizures and metabolic derangements after propofol anesthesia.
Initial symptoms suggested propofol infusion syndrome (PRIS).
Further diagnostic workup revealed neonatal adrenoleukodystrophy (NALD).

Findings:

Neonatal adrenoleukodystrophy (NALD) can present with symptoms overlapping those of propofol infusion syndrome (PRIS).

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Metabolic acidosis, hypertriglyceridemia, and hyperkalemia are key indicators.

The case highlights the importance of comprehensive differential diagnosis.

Implications:

Clinicians should consider NALD in the differential diagnosis of pediatric patients presenting with PRIS-like symptoms.
Early and accurate diagnosis of neurometabolic disorders is crucial for appropriate management.
This case underscores the need to rule out underlying genetic or metabolic conditions before attributing symptoms solely to anesthetic complications.