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Updated: May 15, 2026
09:33
Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks
Published on: March 29, 2018
[Relationship between placental pathology and small-for-gestational age neonates]
Xue-jun Zhao1, Jin-ping Xu, Bing Li
1Department of Pathology, Shanghai Changning District Maternity and Infant Health Hospital, Shanghai, China. zhxuejun.1965@yahoo.com.cn
Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|January 11, 2013
Summary
Placental abnormalities are linked to small-for-gestational-age (SGA) neonates. Gestational hypertension is a primary clinical cause of SGA, impacting fetal growth.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Medicine
- Pathology
Context:
- Small-for-gestational-age (SGA) neonates represent a significant concern in perinatal care.
- Understanding the placental factors contributing to SGA is crucial for improving neonatal outcomes.
Purpose:
- To investigate the association between pathological placental findings and the occurrence of small-for-gestational-age neonates.
- To identify specific placental abnormalities prevalent in SGA cases compared to appropriate-for-gestational-age controls.
Summary:
- A comparative study examined 100 placentas from SGA neonates and 200 from appropriate-for-gestational-age (AGA) neonates.
- SGA placentas exhibited lower volume, weight, and fetal-placental weight ratio, with increased incidence of umbilical cord abnormalities, syncytial knots, avascular villi, and villous infarcts.
- Gestational hypertension and abnormal fetal monitoring were more frequent in the SGA group.
Impact:
- Gestational hypertension disease is identified as a major clinical cause of SGA.
- Specific placental abnormalities can adversely affect intrauterine fetal growth and development, highlighting the placenta's critical role.
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