[Drug resistance and molecular epidemiology of Shigella isolated from children with diarrhea]

Related Experiment Video

Updated: May 15, 2026

Epithelial Cell Infection Analyses with Shigella
04:56

Epithelial Cell Infection Analyses with Shigella

Published on: February 9, 2024

Chuan-ling Zhang1, Li-meng Shen, Xu Chu

  • 1Department of Clinical Laboratory, Xiaoshan Hospital, Hangzhou 311201, China.

Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics
|January 11, 2013
PubMed

Insights

Extended-spectrum beta-lactamases (ESBLs) producing Shigella are increasingly prevalent in children with diarrhea. Piperacillin/tazobactam is recommended for treating infections caused by these resistant strains.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Shigella is a leading cause of bacterial gastroenteritis in children worldwide.
  • Antibiotic resistance in Shigella poses a significant challenge to effective treatment and disease control.

Purpose of the Study:

  • To determine the prevalence and antibiotic resistance patterns of Shigella strains isolated from children with diarrhea.
  • To guide clinical management and inform prevention strategies for bacillary dysentery.

Main Methods:

  • Isolation of Shigella strains from pediatric fecal samples over a three-year period.
  • Antimicrobial susceptibility testing using disk diffusion and phenotypic confirmatory tests for extended-spectrum beta-lactamases (ESBLs).
  • Genotyping of ESBL-producing Shigella sonnei isolates using REP-PCR.

Main Results:

  • Shigella sonnei was the predominant species (83.3%), followed by Shigella flexneri (16.7%).
  • The prevalence of ESBL-producing Shigella increased annually, reaching 59.8% in 2010.
  • High resistance rates were observed for ampicillin, cotrimoxazole, cefotaxime, and piperacillin among ESBL producers. No resistance to piperacillin/tazobactam or imipenem was detected.
  • Genotype A was the most common among ESBL-producing Shigella sonnei.

Conclusions:

  • A high and increasing isolation rate of ESBL-producing Shigella was found in pediatric diarrhea cases.
  • ESBL-producing Shigella sonnei, particularly genotype A, is dominant.
  • Piperacillin/tazobactam is identified as the preferred antibiotic for treating ESBL-producing Shigella infections in children.
Abstract

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