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Two new triterpenoid saponins from the root of Platycodon grandiflorum
Guoxu Ma1, Wenjie Guo, Lizi Zhao
1Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
Abstract:
Two new triterpenoid saponins, named platycodon A (3-O-β-D-glucopyranosyl-16-O-β-D-glucopyranosyl-2β,3β,16β,21β-tetrahydroxyolean-12-en-28-oic acid) and platycodon B (3-O-β-D-glucopyranosyl-16-O-β-D-xylopyranosyl-2β,3β,16β,21β-tetrahydroxyolean-12-en-28-oic acid) were isolated from the roots of Platycodon grandiflorum. The structures of these compounds were elucidated by means of various spectroscopic analyses. Compounds 1 and 2 were tested in HepG-2, A549 and DU145 human cancer cell lines and showed remarkable cytotoxic activities against HepG-2 and A549 cancer cell lines with IC(50) values ranging from 4.9 to 9.4 µM, but they displayed weak cytotoxic activities against DU145 cancer cell line with IC(50) values greater than 10 µM.
