Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bootstrapping01:24

Bootstrapping

The term "bootstrap" originated in the 19th century as a metaphor for self-improvement or achieving something independently, without external assistance. This concept extends to statistical bootstrapping, a self-contained method for estimating population parameters through resampling, even though it can be computationally intensive. Developed by the American statistician Dr. Bradley Efron in 1979, bootstrapping provides a robust way to perform inference when the original sample size is small or...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood IL-6 is a critical trigger of depressive symptoms in a mouse model for human atopic dermatitis.

Translational psychiatry·2026
Same author

Soluble bacterial lipopeptides suppress gasdermin D-associated IL-33 release in keratinocytes and atopic dermatitis in mice.

Nature communications·2026
Same author

An arterial spin-labeled magnetic resonance imaging study of brain activation in patients with major depressive disorder during acupuncture stimulation: An exploratory study.

Psychiatry research. Neuroimaging·2026
Same author

Optimized Infrared Reflection-Absorption Spectroscopy Using Indium Tin Oxide as Thin-Film Supporting Substrates.

Applied spectroscopy·2026
Same author

Semi-quantitative tau PET approaches for Braak staging: concordance of CenTauRz and STOC with visual assessment.

Annals of nuclear medicine·2026
Same author

[SPECT Imaging].

Brain and nerve = Shinkei kenkyu no shinpo·2026

Related Experiment Video

Updated: May 15, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

Statistical evaluation of single-photon emission computed tomography image using smoothed bootstrap method.

Megumi Tsukamoto1, Asuka Hatabu, Yoshitake Takahashi

  • 1Faculty of Pharmaceutical Sciences, Osaka University, 1–6 Yamadaoka, Suita, Osaka 565–0871, Japan.

Biological & Pharmaceutical Bulletin
|January 11, 2013
PubMed
Summary

This study introduces a new statistical method for diagnosing neurodegenerative diseases by analyzing regional cerebral blood flow (rCBF). The nonparametric bootstrap approach provides reliable Z-score distributions for objective diagnosis, aiding early detection and disease management.

More Related Videos

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin
09:36

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin

Published on: March 14, 2018

Related Experiment Videos

Last Updated: May 15, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin
09:36

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin

Published on: March 14, 2018

Area of Science:

  • Neuroimaging
  • Neurology
  • Biostatistics

Background:

  • Neurodegenerative diseases often involve decreased regional cerebral blood flow (rCBF), necessitating early diagnosis for effective management.
  • Current diagnostic imaging methods like PET and SPECT have limitations in objective visual evaluation.
  • Existing statistical methods for image analysis may rely on inappropriate data distribution assumptions.

Purpose of the Study:

  • To develop a novel statistical procedure for objectively evaluating decreased rCBF.
  • To establish a method that does not require assumptions about data distribution for Z-score calculation.
  • To enable more accurate and timely diagnosis of neurodegenerative diseases.

Main Methods:

  • Proposed a new procedure using nonparametric or smoothed bootstrap methods.
  • Calculated a standardized distribution of the Z-score without data distribution assumptions.
  • Applied the procedure to a sufficiently large sample dataset for validation.

Main Results:

  • The new procedure successfully calculated standardized Z-score distributions.
  • Evaluations using the proposed method were equivalent to traditional Z-score evaluations with fixed thresholds.
  • Demonstrated the reliability of the nonparametric approach for rCBF analysis.

Conclusions:

  • The proposed nonparametric bootstrap method offers a robust alternative for evaluating rCBF.
  • This approach enhances the objectivity and accuracy of diagnosing diseases associated with decreased rCBF.
  • Facilitates earlier and more definitive diagnoses, crucial for managing progressive neurodegenerative conditions.