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An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

Candida albicans pathogenicity mechanisms.

François L Mayer1, Duncan Wilson, Bernhard Hube

  • 1Department of Microbial Pathogenicity Mechanisms, Hans-Knoell-Institute, Jena, Germany.

Virulence
|January 11, 2013
PubMed
Summary
This summary is machine-generated.

Candida albicans, a common fungus, can cause serious infections by employing various virulence factors. This review updates our knowledge on how these mechanisms contribute to pathogenicity.

Keywords:
Candida albicanscandidiasisfitness attributespathogenicityvirulence factors

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Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Related Experiment Videos

Last Updated: May 15, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Area of Science:

  • Mycology
  • Infectious Diseases
  • Microbiology

Background:

  • Candida albicans is a common human commensal fungus.
  • It can transition from harmless to pathogenic, causing superficial to systemic infections.
  • Understanding its virulence factors is crucial for treating infections.

Purpose of the Study:

  • To provide an updated review of Candida albicans pathogenicity mechanisms.
  • To highlight recent discoveries in fungal virulence.
  • To consolidate current knowledge on host-pathogen interactions.

Main Methods:

  • Literature review of recent research on Candida albicans virulence.
  • Analysis of identified pathogenic factors and mechanisms.
  • Synthesis of findings on host cell adhesion, invasion, and immune evasion.

Main Results:

  • Key virulence factors include adhesion molecules, hydrolases, yeast-to-hypha transition, and biofilm formation.
  • Phenotypic switching and fitness attributes also contribute to pathogenicity.
  • Novel virulence mechanisms have been recently identified.

Conclusions:

  • Significant progress has been made in understanding Candida albicans virulence.
  • Updated knowledge aids in developing strategies against candidiasis.
  • Further research into novel mechanisms is ongoing.