Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 15, 2026

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

Graphene-modified interdigitated array electrode: fabrication, characterization, and electrochemical immunoassay

Yuko Ueno1, Kazuaki Furukawa, Katsuyoshi Hayashi

  • 1NTT Microsystem Integration Laboratories, NTT Corporation, Atsugi, Kanagawa, Japan. ueno.yuko@lab.ntt.co.jp

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
|January 11, 2013
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thermally Degradable Water Diffusion Barrier Assembled by Gelatin and Beeswax toward Edible Electronics.

ACS applied materials & interfaces·2024
Same author

Structural and Mechanical Characterization of DNA-Tethered Membranes on Graphene.

Langmuir : the ACS journal of surfaces and colloids·2024
Same author

Enhancing Type 2 Diabetes Treatment Decisions With Interpretable Machine Learning Models for Predicting Hemoglobin A1c Changes: Machine Learning Model Development.

JMIR AI·2024
Same author

Treatment Discontinuation Prediction in Patients With Diabetes Using a Ranking Model: Machine Learning Model Development.

JMIR bioinformatics and biotechnology·2024
Same author

Noninvasive Glucose Sensing in Dielectrically Equivalent Multilayer Skin Phantoms.

Langmuir : the ACS journal of surfaces and colloids·2023
Same author

Control of rotation angles of multilayer graphene on SiC (0001‾) by substrate off-direction and angle.

Journal of physics. Condensed matter : an Institute of Physics journal·2023

We developed a new method for creating reduced graphene oxide-modified gold electrodes (rGO/Au-IDA) for sensitive electrochemical assays. This technique enhances detection sensitivity, enabling accurate measurement of biomarkers like cortisol in saliva.

Area of Science:

  • Electrochemistry
  • Materials Science
  • Nanotechnology

Background:

  • Interdigitated array gold electrodes (Au-IDA) are crucial for electrochemical sensing.
  • Graphene oxide (GO) modification can enhance electrode performance.
  • Short-circuiting is a challenge in fabricating modified electrodes.

Purpose of the Study:

  • To develop a novel fabrication procedure for reduced graphene oxide-modified interdigitated array gold electrodes (rGO/Au-IDA).
  • To investigate the electrochemical properties of the rGO/Au-IDA for detecting p-aminophenol (pAP).
  • To demonstrate the application of rGO/Au-IDA in a quantitative electrochemical immunoassay for cortisol detection.

Main Methods:

  • Fabrication of Au-IDA modified with graphene oxide (GO) followed by reduction to rGO.

More Related Videos

Iridium Oxide-reduced Graphene Oxide Nanohybrid Thin Film Modified Screen-printed Electrodes as Disposable Electrochemical Paper Microfluidic pH Sensors
09:15

Iridium Oxide-reduced Graphene Oxide Nanohybrid Thin Film Modified Screen-printed Electrodes as Disposable Electrochemical Paper Microfluidic pH Sensors

Published on: November 22, 2016

Related Experiment Videos

Last Updated: May 15, 2026

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

Iridium Oxide-reduced Graphene Oxide Nanohybrid Thin Film Modified Screen-printed Electrodes as Disposable Electrochemical Paper Microfluidic pH Sensors
09:15

Iridium Oxide-reduced Graphene Oxide Nanohybrid Thin Film Modified Screen-printed Electrodes as Disposable Electrochemical Paper Microfluidic pH Sensors

Published on: November 22, 2016

  • Electrochemical characterization using p-aminophenol (pAP) as a probe.
  • Demonstration of cortisol detection in human saliva using the developed rGO/Au-IDA.

    • Main Results:

    • A new procedure successfully fabricated rGO/Au-IDA, preventing short-circuiting.
    • Electrode reactivity for pAP detection increased with denser rGO.
    • Established redox cycling at rGO/Au-IDA enhanced detection sensitivity compared to single electrodes.
    • Quantitative detection of cortisol in human saliva was achieved.

    Conclusions:

    • The developed fabrication method for rGO/Au-IDA is effective and prevents electrode short-circuiting.
    • The rGO/Au-IDA exhibits enhanced electrochemical activity and sensitivity for analyte detection.
    • rGO/Au-IDA serves as a promising platform for sensitive electrochemical immunoassays, exemplified by cortisol detection.