[Lipid peroxidation in patients with chronic adrenal cortex failure]

The investigation of 55 patients with chronic adrenocortical insufficiency has shown an increase in the intensity of lipid peroxidation against a background of blood plasma alpha-tocopherol (the main endogenous antioxidant) concentration. The use of vitamin E in multimodality treatment together with substitution hormone therapy resulted in the normalization of indices of lipid peroxidation and antioxidant system necessitating the incorporation of the drug in therapeutic measures in chronic adrenocortical insufficiency.