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Updated: May 15, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Lymphoproliferative disorder that resembles heptosplenic lymphoma during maintenance treatment for T-cell acute
Youjun Hu1, Tahmeena Ahmed, Ann-Leslie Zaslav
1Division of Pathology and Laboratory Medicine, Stony Brook University Medical Center, Stony Brook, New York.
Abstract:
A 6-year-old male presented with a testicular mass, hepatosplenomegaly, and a pleural effusion while undergoing maintenance chemotherapy for treatment of T-cell acute lymphoblastic leukemia (T-ALL). He was subsequently diagnosed with a lymphoproliferative disorder that resembled hepatosplenic lymphoma (HSL). While the extranodal presentation and the protracted yet aggressive clinical course are consistent with HSL, the findings of monosomy 8 and polymorphic cell populations are unique and have not been previously described in this type of lymphoma.
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