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Multivessel coronary thrombosis in a patient with idiopathic thrombocytopenic purpura

Julide Yagmur1, Mehmet Cansel, Nusret Acikgoz

  • 1Department of Cardiology, Faculty of Medicine, Inonu University, 44100 Malatya, Turkey. julideyagmur@hotmail.com

Texas Heart Institute Journal
|January 11, 2013
PubMed

Insights

A patient with idiopathic thrombocytopenic purpura experienced myocardial infarction due to coronary artery thrombi. Tirofiban effectively dissolved these thrombi, resolving the condition.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by low platelet counts.
  • Myocardial infarction (MI) is a serious condition resulting from blocked blood flow to the heart muscle.

Observation:

  • A 49-year-old female patient with a history of ITP presented with severe chest pain.
  • Electrocardiography confirmed inferolateral myocardial infarction.
  • Coronary angiography identified extensive thrombi occluding distal segments of multiple coronary arteries.

Findings:

  • Percutaneous coronary intervention was not feasible due to the widespread occlusion.
  • Intravenous administration of tirofiban, a glycoprotein IIb/IIIa inhibitor, successfully dissolved the coronary thrombi.
  • The patient's condition improved following thrombolysis with tirofiban.

Implications:

  • Tirofiban can be an effective treatment option for acute coronary syndromes caused by extensive thrombi in patients with ITP.
  • This case highlights the importance of considering thrombotic complications in patients with ITP presenting with ischemic symptoms.
  • Further research may explore the role of antiplatelet agents in managing coronary artery thrombosis in ITP patients.

Keywords:
Coronary thrombosis, multivesselmyocardial infarctionplatelet aggregation inhibitors/therapeutic usepurpura, thrombocytopenic, idiopathic/therapytirofiban

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