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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
Mutations01:39

Mutations

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Updated: May 15, 2026

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
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Environmental factors inducing human cancers.

N Parsa1

  • 1National Institutes of Health, Bethesda, MD, USA.

Iranian Journal of Public Health
|January 11, 2013
PubMed
Summary
This summary is machine-generated.

Environmental factors significantly impact human health, with carcinogens initiating genetic mutations that disrupt normal cell division. Reducing exposure to environmental carcinogens is crucial for cancer prevention and improving health outcomes.

Keywords:
Cancer causing genesEnvironmental factorsHuman cancers

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Area of Science:

  • Environmental health
  • Molecular genetics
  • Cancer biology

Background:

  • Extensive research links environmental factors to human health issues.
  • Environmental carcinogens can disrupt cellular networking and initiate genetic mutations.
  • These mutations affect key genes involved in cell division, including oncogenes and tumor suppressor genes.

Purpose of the Study:

  • To discuss the impact of environmental cancer-causing factors on human health.
  • To explain how these factors disrupt cellular networking and genetic pathways.
  • To highlight the role of molecular genetics in understanding and combating cancer.

Main Methods:

  • Review of existing research on environmental factors and cancer.
  • Analysis of genetic mutations in oncogenes, tumor suppressor genes, apoptosis genes, and DNA repair genes.
  • Discussion of molecular genetics techniques in cancer screening, diagnosis, prognosis, and therapy.

Main Results:

  • Environmental factors can initiate a cascade of genetic mutations.
  • Alterations in specific gene groups (oncogenes, tumor suppressors, apoptosis, DNA repair) are critical in cancer development.
  • Molecular genetics provides advanced tools for cancer management.

Conclusions:

  • Environmental carcinogen exposure is a significant public health concern.
  • Understanding genetic mutations is key to cancer prevention and treatment.
  • Minimizing exposure to environmental carcinogens should be a primary goal for cancer prevention programs.