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Updated: May 15, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
An investigation of cephalometric and morphological predictors of successful twin block therapy
Padhraig S Fleming1, Usman Qureshi, Nikolaos Pandis
1Institute of Dentistry, Queen Mary University of London, London, United Kingdom. padhraig.fleming@gmail.com
Objective:
To identify predictors of overjet reduction, changes in mandibular length (Co-Me) and antero-posterior changes in mandibular position (Pog-Vert) during Twin Block therapy.
Methods:
Pre- and post-treatment cephalograms of 131 participants were analysed (Mean age 12.73 years +/- 1) following Twin Block therapy.
Results:
Mean annualised overjet reduction was 7.29 mm (+/- 2.99) with chin projection improving by 2.66 mm (+/- 5.37). The magnitude of the initial overjet was a strong predictor (95% CI: 0.30, 0.77, p < 0.01) of overjet reduction and change in chin position (95% CI: 0.08, 0.77, p = 0.02). Greater forward movement of Pogonion occurred if there was greater retrusion of Pogonion at the outset (95% CI: 0.15, 0.45, p < 0.01). No prognostic relationship was noted for other potential cephalometric predictors including pretreatment mandibular lower border morphology and Co-Go-Me angle.
Conclusion:
No relationship between mandibular morphology, vertical skeletal pattern and favourable dentoalveolar and skeletal responses to Twin Block therapy could be found. These results require confirmation on an external sample.
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