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Updated: May 15, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
[The hormonal metabolic alterations in patients in critical state]
Abstract:
It is established that in patients in critical state occur significant alterations of hormone metabolic parameters. In severe cases, hypermetabolism-hyperkatabolism syndrome is developed. Under this syndrome, the resistance to exogenous introduction of nutrients occurs. The syndrome plays a key role in in pathogenesis of critical state and its course in many respects determine outcome of disease. The article describes in detail the pathogenesis of all cascades of pathologic reactions in severe ill patients subject to pathogenic mechanism of development. The possible approaches to resolve this complicated issue are presented.
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