Related Experiment Video
Updated: May 15, 2026
06:23
Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
Ankylosing spondylitis associated with Sweet's syndrome: a case report
Samia Mansouri1, Fatima Ezzahra Abourazzak, Nassira Aradoini
1Rheumatology Department, Hassan II University Hospital, Fez, Morocco. samuela.med@hotmail.com.
Journal of Medical Case Reports
|January 12, 2013
Summary
This case study highlights a rare association between Sweet's syndrome, an acute neutrophilic dermatosis, and ankylosing spondylitis. The findings suggest a potential link between these conditions, warranting further investigation.
Area of Science:
- Dermatology
- Rheumatology
- Immunology
Background:
- Sweet's syndrome is an acute neutrophilic dermatosis with diverse triggers, including idiopathic, drug-induced, or associated with underlying diseases.
- The co-occurrence of Sweet's syndrome and ankylosing spondylitis is exceptionally rare, with limited documented cases.
- This report details a novel instance where an acute neutrophilic dermatosis presentation unveiled underlying ankylosing spondylitis.
Purpose of the Study:
- To present a rare case of Sweet's syndrome revealing ankylosing spondylitis.
- To contribute to the limited literature on this specific association.
- To emphasize the importance of considering systemic inflammatory conditions in patients presenting with Sweet's syndrome.
Main Methods:
- A case presentation of a 33-year-old male with polyarthralgia, spinal pain, fever, and characteristic skin lesions.
- Diagnostic workup included laboratory tests (leukocytosis, elevated ESR/CRP), negative infectious and neoplastic markers, MRI revealing sacroiliitis, and skin biopsy confirming Sweet's syndrome.
- Treatment involved nonsteroidal anti-inflammatory drugs, leading to rapid clinical improvement.
Main Results:
- The patient exhibited symptoms consistent with both Sweet's syndrome and ankylosing spondylitis, including fever, skin lesions, joint pain, and sacroiliitis.
- Diagnostic investigations confirmed the co-existence of these two conditions.
- The patient responded well to nonsteroidal anti-inflammatory drug therapy.
Conclusions:
- The association between Sweet's syndrome and ankylosing spondylitis, though rare, is supported by this case and previous literature.
- The underlying mechanisms driving this association remain unclear and require further research.
- This case underscores the need for comprehensive evaluation in patients with Sweet's syndrome to identify potential underlying systemic inflammatory diseases like ankylosing spondylitis.
