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Related Experiment Videos

Cough threshold after upper abdominal surgery.

J P Dilworth1, J C Pounsford, R J White

  • 1Department of Medicine, Frenchay Hospital, Bristol.

Thorax
|March 1, 1990
PubMed
Summary
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Upper abdominal surgery under general anesthesia temporarily increases cough threshold, reducing cough sensitivity to inhaled irritants. This effect, observed on the first postoperative day, returns to normal by the fourth day.

Area of Science:

  • Anesthesiology
  • Respiratory Medicine
  • Surgical Outcomes

Background:

  • General anesthesia and upper abdominal surgery can impact respiratory function.
  • Postoperative cough reflex sensitivity is a critical factor in recovery and complication prevention.

Purpose of the Study:

  • To investigate the effect of upper abdominal surgery under general anesthesia on the cough threshold.
  • To assess changes in cough sensitivity to chemical irritants in the early postoperative period.

Main Methods:

  • Twenty-six patients undergoing upper abdominal surgery were studied.
  • Cough thresholds for capsaicin and citric acid aerosols were measured preoperatively, and on postoperative days 1 and 4.
  • Doubling doses of nebulized irritants were administered to determine cough-inducing concentrations.

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Main Results:

  • A significant increase in cough threshold (decreased cough sensitivity) was observed on postoperative day 1 for both capsaicin and citric acid.
  • Cough sensitivity returned towards preoperative levels by postoperative day 4.
  • The increase in cough threshold on day 1 correlated with the time since opiate administration.

Conclusions:

  • Upper abdominal surgery under general anesthesia transiently diminishes cough reflex sensitivity.
  • This reduced sensitivity to inhaled chemical irritants is most pronounced on the first postoperative day.
  • Opiate administration timing may influence the degree of postoperative cough suppression.