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Novel pulsatile diagonal pump for pediatric extracorporeal life support system
Shigang Wang1, Allen R Kunselman, Akif Ündar
1Department of Pediatrics, Surgery and Bioengineering, Penn State Hershey Pediatric Cardiovascular Research Center, Penn State Hershey Children's Hospital, Hershey, PA 17033-0850, USA.
Artificial Organs
|January 12, 2013
Summary
The Medos Deltastream DP3 diagonal pump effectively generates pulsatile flow for pediatric extracorporeal life support (ECLS), offering higher flow rates and hemodynamic energy compared to nonpulsatile methods.
Area of Science:
- Biomedical Engineering
- Cardiovascular Technology
- Pediatric Critical Care
Background:
- Extracorporeal life support (ECLS) is crucial for critically ill patients.
- Pulsatile flow pumps are being explored for improved ECLS performance.
- The Medos Deltastream DP3 is a novel pulsatile rotary flow pump used in European ECLS.
Purpose of the Study:
- To evaluate the performance of the Medos Deltastream DP3 diagonal pump.
- To assess its efficacy in a simulated pediatric ECLS system.
- To compare pulsatile vs. nonpulsatile flow characteristics.
Main Methods:
- Simulated pediatric ECLS circuit using Medos Hilite 800LT oxygenator and Deltastream DP3 pump.
- Flow rates from 200-800 mL/min at 35°C with human blood (40% hematocrit).
- Real-time pressure and flow data acquisition with a Labview-based system.
Main Results:
- Medos Deltastream DP3 generated effective pulsatile flow without backflow.
- Pulsatile flow achieved higher rates and pressures than nonpulsatile flow.
- Increased pulsatility correlated with speed differential and flow rates; oxygenator pressure drop remained acceptable.
Conclusions:
- The Medos Deltastream DP3 provides adequate pulsatility without backflow in simulated pediatric ECLS.
- Pulsatile mode generates superior hemodynamic energy compared to nonpulsatile mode.
- This pump shows promise for enhancing pediatric ECLS therapy.