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Published on: December 5, 2025
Bubble CPAP versus ventilator CPAP in preterm neonates with early onset respiratory distress--a randomized controlled
Amit Tagare1, Sandeep Kadam, Umesh Vaidya
1Division of Neonatology, Department of Pediatrics, KEM Hospital, Pune 411011, India.
Unlabelled:
Bubble continuous positive airway pressure (BCPAP) is a low cost nasal CPAP delivery system with potential benefits to developing nations.
Objective:
To compare the efficacy and safety of BCPAP with ventilator-derived CPAP (VCPAP) in preterm neonates with respiratory distress.
Methods:
In a randomized controlled trial, preterm neonates with Silverman-Anderson score ≥ 4 and oxygen requirement >30% within first 6 h of life were randomly allocated to BCPAP or VCPAP. Proportion of neonates with success or failure was compared.
Results:
In all, 47 of 57 (82.5%) neonates from BCPAP group and 36 of 57 (63.2%) neonates from the VCPAP group completed CPAP successfully (p = 0.03). Neonates who failed CPAP had higher Silverman-Anderson score (p < 0.01), lower arterial to alveolar oxygenation ratio (p < 0.05) and needed surfactant more frequently (p < 0.01).
Conclusion:
BCPAP has higher success rate than VCPAP for managing preterm neonates with early onset respiratory distress, with comparable safety.
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