Related Experiment Video
Updated: May 15, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
Cell-penetrating peptides (CPPs) as a vector for the delivery of siRNAs into cells
Ikuhiko Nakase1, Gen Tanaka, Shiroh Futaki
1Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Abstract:
"Cell-penetrating peptides (CPPs)" is an inclusive term describing relatively small peptides (6-30 amino acid residues) having membrane translocation activity. Due to their efficacy in cellular internalisation and the accompanying low cytotoxicity, CPPs are regarded as promising vectors for intracellular delivery of various membrane-impermeable bioactive molecules. This review provides an overview of the current approaches and describes the potential of CPP-based siRNA delivery systems, specifically those using arginine-rich CPPs.
Related Concept Videos
Experimental RNAi
siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
RNA Interference
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...

