Related Experiment Video

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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))
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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))

Published on: May 4, 2020

A case of acute prochloraz-manganese complex intoxication treated with extracorporeal elimination

Hyowook Gil1, Sujin Seok, Jungrak Hong

  • 1Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.

Blood Purification
|January 12, 2013
PubMed
Abstract

Insights

This case study shows that aggressive extracorporeal elimination effectively treated severe manganese intoxication. The patient recovered from shock and regained consciousness after intensive treatment.

Area of Science:

  • Toxicology
  • Nephrology
  • Critical Care Medicine

Background:

  • Acute manganese intoxication is a rare but serious condition.
  • Prompt and aggressive treatment is crucial for patient survival and recovery.
  • Extracorporeal elimination methods offer a potential therapeutic strategy.

Observation:

  • A 65-year-old male presented with critical manganese intoxication after ingesting a prochloraz-manganese complex.
  • The patient experienced circulatory collapse and coma, requiring mechanical ventilation.
  • Treatment involved hemoperfusion, hemodialysis, and continuous venovenous hemodiafiltration (CVVHDF) with norepinephrine support.

Findings:

  • Manganese levels significantly decreased from 34.1 µg/l on day 1 to 12.5 µg/l on day 4.
  • The patient stabilized from shock within 7 days.
  • Full consciousness was regained after 4 weeks of intensive care.

Implications:

  • Vigorous extracorporeal elimination is a viable and effective treatment for acute manganese intoxication.
  • This case highlights the importance of multi-modal renal replacement therapies in managing severe toxic exposures.
  • Successful management underscores the potential for recovery even in critical poisoning cases.

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