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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Is the future of statins aligned with new novel lipid modulation therapies?

Binh An P Phan1, Peter P Toth

  • 1Loyola University Chicago Stritch School of Medicine, Loyola University Medical Center, 2160 S. First Avenue, Bldg 110, Rm 6221, Maywood, IL 60153, USA. bphan@lumc.edu

Current Atherosclerosis Reports
|January 12, 2013
PubMed

Insights

New lipid-altering therapies are being developed to address residual cardiovascular risk in patients with dyslipidemia who do not reach treatment goals with statins alone. These novel agents aim to improve atherogenic lipoprotein levels and potentially increase high-density lipoprotein cholesterol.

Area of Science:

  • Cardiology
  • Pharmacology
  • Biochemistry

Background:

  • Dyslipidemia is a major risk factor for atherosclerotic cardiovascular disease.
  • Statin therapy is the primary treatment but leaves many patients with residual cardiovascular risk.
  • There is a need for additional therapies to improve lipid profiles and reduce cardiovascular events.

Purpose of the Study:

  • To review novel lipid-altering therapies currently in clinical trials.
  • To discuss agents that can augment statin therapy for dyslipidemia.
  • To highlight potential adjuvant treatments for atherosclerotic heart disease.

Main Methods:

  • Review of current clinical trial data for novel lipid-modulating agents.
  • Discussion of mechanisms of action for emerging therapies.
  • Analysis of the role of these agents in managing dyslipidemia.

Main Results:

  • Several novel therapies show promise in lowering atherogenic lipoproteins and managing dyslipidemia.
  • Emerging agents include PCSK9 inhibitors, apolipoprotein B antisense oligonucleotides, microsomal transfer protein inhibitors, thyroid mimetics, and cholesteryl ester transfer protein inhibitors.
  • These therapies offer potential to address residual risk beyond statin treatment.

Conclusions:

  • Novel lipid-altering therapies are crucial for managing patients with dyslipidemia who have not achieved treatment goals.
  • These agents may serve as important adjuvant therapies to statins in reducing cardiovascular risk.
  • Further research and clinical trials are needed to establish the role of these emerging treatments in atherosclerotic heart disease management.

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