[Current view on the pathogenetic factors of hypoxia in middle-aged and aged persons]

Pulmonary ventilation, gas exchange, respiration biomechanics, respiratory function of the blood, and the tissue level of PO2 in functional tests have been studied in a group of healthy individuals aged 20-106 years. Aging has been found to be associated with oxygen deficiency including the circulatory and tissue hypoxia elements. The relationship between hypoxia and aging has been confirmed, and the mechanisms by which specific oxygen-deficiency components develop have been outlined. The adaptive hypoxia-related changes in elderly and senile ages have been specified. Based on the current concepts of the pathogenic factors underlying hypoxia in aging, the methodologies are proposed to reverse the hypoxia-related changes in these age groups.