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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Antimicrobial stewardship in pediatric care: strategies and future directions

Jason G Newland1, Ritu Banerjee, Jeffrey S Gerber

  • 1Section of Infectious Diseases, Department of Pediatrics, University of Missouri-Kansas City, Children's Mercy Hospitals & Clinics, Kansas City, Missouri 64108, USA. jnewland1@cmh.edu

Pharmacotherapy
|January 12, 2013
PubMed

Insights

Pediatric antimicrobial stewardship programs (ASPs) are crucial for combating antimicrobial resistance. This review outlines their development, impact, and future research needs in children.

Area of Science:

  • Pediatric infectious diseases
  • Antimicrobial stewardship
  • Public health

Background:

  • Antimicrobial resistance is a growing global threat, necessitating judicious antimicrobial use.
  • New antimicrobial drug development is declining, increasing the importance of existing therapies.
  • Pediatric antimicrobial stewardship programs (ASPs) are essential but face unique challenges.

Purpose of the Study:

  • To describe the development process of pediatric ASPs.
  • To review current data on the effectiveness of pediatric ASPs.
  • To identify priorities and challenges for future pediatric ASP research.

Main Methods:

  • This review synthesizes existing literature on pediatric antimicrobial stewardship.
  • It examines data on the impact and outcomes of implemented pediatric ASPs.
  • It analyzes challenges in study design and endpoint selection for pediatric ASP research.

Main Results:

  • Pediatric ASPs are vital for optimizing antimicrobial prescribing in children.
  • Evidence demonstrates the positive impact of pediatric ASPs on prescribing quality and safety.
  • Key challenges include specific pediatric considerations and research methodology.

Conclusions:

  • Developing and implementing pediatric ASPs is critical for combating antimicrobial resistance.
  • Further research is needed to refine study designs and establish appropriate endpoints for pediatric ASPs.
  • Addressing unique pediatric issues is paramount for effective antimicrobial stewardship in children.

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