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Updated: May 15, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
Methicillin-resistant Staphylococcus aureus (MRSA): colonisation and pre-operative screening
N Goyal1, A Miller, M Tripathi
1Anderson Orthopaedic Clinic, 2445 Army Navy Drive, Arlington, Virginia 22206, USA. ngoyal1@gmail.com
Abstract:
Staphylococcus aureus is one of the leading causes of surgical site infection (SSI). Over the past decade there has been an increase in methicillin-resistant S. aureus (MRSA). This is a subpopulation of the bacterium with unique resistance and virulence characteristics. Nasal colonisation with either S. aureus or MRSA has been demonstrated to be an important independent risk factor associated with the increasing incidence and severity of SSI after orthopaedic surgery. Furthermore, there is an economic burden related to SSI following orthopaedic surgery, with MRSA-associated SSI leading to longer hospital stays and increased hospital costs. Although there is some controversy about the effectiveness of screening and eradication programmes, the literature suggests that patients should be screened and MRSA-positive patients treated before surgical admission in order to reduce the risk of SSI.
Insights
Nasal Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA) colonization increase surgical site infection (SSI) risk in orthopaedic surgery. Pre-operative screening and treatment of MRSA-positive patients may reduce SSI incidence and associated healthcare costs.
Area of Science:
- Infectious Diseases
- Orthopaedic Surgery
- Microbiology
Background:
- Staphylococcus aureus is a primary cause of surgical site infections (SSI).
- Methicillin-resistant S. aureus (MRSA) is a growing concern due to unique resistance and virulence.
- Nasal colonization by S. aureus or MRSA is a significant risk factor for SSI after orthopaedic surgery.
Purpose of the Study:
- To highlight the link between nasal S. aureus/MRSA colonization and SSI in orthopaedic patients.
- To discuss the economic impact of MRSA-associated SSIs.
- To evaluate the potential benefits of pre-operative screening and eradication protocols.
Main Methods:
- Literature review on S. aureus/MRSA nasal colonization and SSI.
- Analysis of risk factors and patient outcomes.
- Examination of economic implications of SSIs.
Main Results:
- Nasal S. aureus and MRSA colonization are independent risk factors for SSI incidence and severity.
- MRSA-associated SSIs result in prolonged hospital stays and increased costs.
- Screening and eradication show potential for SSI risk reduction.
Conclusions:
- Pre-operative screening for MRSA is recommended for orthopaedic surgery patients.
- Treatment of MRSA-colonized patients before surgery can mitigate SSI risks.
- Addressing S. aureus and MRSA nasal carriage is crucial for improving surgical outcomes.
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